Submitter: ICAR
Multi-drug resistant (MDR) pathogens, particularly Escherichia coli and non-typhoidal Salmonella spp. (NTS) are a major challenge in public health due to their apparent spread within poultry and their associated environments. With the limited antibiotic drug discovery pipelines, currently, non-clinical and clinical research is now invested in the identification of novel and non-conventional anti-infective adjunctive or preventive therapies. Though various phytochemicals alone or their combinations with antibiotics have been tried with success to address multi-drug resistant (MDR) pathogens, particularly Escherichia coli and non-typhoidal Salmonella spp. (NTS) in poultry; however, their long-term use may not be effective owing to the development of resistance, and also stability issues of the phytochemicals when administered alone. Hence, to improve the stability, bioavailability, and release of these phytochemical compounds, we identified a unique combination of encapsulated nanosilver-entrapped phytochemical molecules as a novel green strategy to address MDR pathogen-driven ailments and associated diseases in the poultry industry.
The unique features of the developed technology are as follows.
The developed innovation has been studied for toxicological parameters as per OECD 425 guidelines and also validated in the field and was found to be safe and effective. In brief, the encapsulated compounds (EAgC, EAgT) derived from the present study were found to inhibit bacterial growth and improve survival rate with minimal toxicity in appropriate in vitro assays and in vivo models, with an improved feed conversion ratio (FCR) in poultry and leaving no residues of the innovated compounds in poultry meat which is crucial for food safety and consumer health. The innovative molecules are supposed to provide an appropriate delivery system at the targeted site, which means the compounds are designed to reach the specific sites where the targeted pathogens are often encountered. This approach not only reduces the required dose by also reduces overall production costs. To conclude, this innovative technology presents a promising green approach to inhibit bacterial growth, improve survival rates, and combat antibiotic resistance while maintaining food safety standards. It also emphasizes the potential economic benefits and the possibility of developing a commercially viable product based on these innovations.
Dr. Raghavendra Bhatta, Deputy Director General (Animal Science) Division of Animal Science, Krishi Bhavan, New Delhi - 110 001, INDIA ;
Phone: +91-11-23381119,
Email id: ddgas.icar@nic.in
